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Objective@#To analyze the multiple mediating effects of ruminant thinking and mental resilience on ICU related memory and post-traumatic stress disorder in patients with hepatic ischemia reperfusion injury, and to provide guidance for the psychological intervention of patients with hepatic ischemia-reperfusion injury.@*Methods@#Totally 522 cases of patients with hepatic ischemia reperfusion injury were selected and selected from four three-class superior hospitals in Harbin City and two three-class superior hospitals in Shenzhen City from January 2017 to December 2017. To investigate ICU related-memory, post-traumatic stress disorder, ruminant thinking and resilience, and to analyze ICU related memory and post traumatic stress in ruminant thinking and heart elasticity Multiple mediating effects between obstacles.@*Results@#The scores of ICU-related memories in patients with hepatic ischemia reperfusion injury were (64.18±10.34) points, the score of ruminant thinking was (63.15±8.21) points, the score of mental resilience was (62.34±8.41) points, and the score of post-traumatic stress disorder was (40.74±10.24) points. There were significant positive correlations between 22 patients with ICU related memory, ruminant thinking and post-traumatic stress barrier (ICU-related memory vs. ruminant thinking, r=0.777; ICU-related memory vs. post-traumatic stress disorder, r=0.724; ruminant thinking vs. post-traumatic stress disorder, r=0.734, P<0.01), which had a significant negative correlation with mental resilience (r=-0.718, -0.722, P<0.01). There was only a partial mediation effect between resilience and ruminant thinking in the relation of ICU related memory and post-traumatic stress disorder. Which took mediating effect at 29.0% and 20.7% of the total effect. Resilience-self-efficacy had a chain mediated effect between ICU related memory and post-traumatic stress disorder, with an effective value of 0.36, accounting for 15.6% of the total effect.@*Conclusion@#The ruminant thinking and ICU related-memory can be inhibited and the post-traumatic stress disorder can be alleviated by improving the mental resilience level of the patients with hepatic ischemia reperfusion injury from ICU.
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Objective To analyze the multiple mediating effects of ruminant thinking and mental resilience on ICU related memory and post-traumatic stress disorder in patients with hepatic ischemia reperfusion injury, and to provide guidance for the psychological intervention of patients with hepatic ischemia-reperfusion injury. Methods Totally 522 cases of patients with hepatic ischemia reperfusion injury were selected and selected from four three-class superior hospitals in Harbin City and two three-class superior hospitals in Shenzhen City from January 2017 to December 2017. To investigate ICU related-memory, post-traumatic stress disorder, ruminant thinking and resilience, and to analyze ICU related memory and post traumatic stress in ruminant thinking and heart elasticity Multiple mediating effects between obstacles. Results The scores of ICU-related memories in patients with hepatic ischemia reperfusion injury were (64.18±10.34) points, the score of ruminant thinking was (63.15±8.21) points, the score of mental resilience was (62.34 ± 8.41) points, and the score of post-traumatic stress disorder was (40.74±10.24) points. There were significant positive correlations between 22 patients with ICU related memory, ruminant thinking and post-traumatic stress barrier (ICU-related memory vs. ruminant thinking, r=0.777; ICU-related memory vs. post-traumatic stress disorder, r=0.724; ruminant thinking vs. post-traumatic stress disorder, r=0.734, P<0.01), which had a significant negative correlation with mental resilience (r=-0.718,-0.722, P<0.01). There was only a partial mediation effect between resilience and ruminant thinking in the relation of ICU related memory and post-traumatic stress disorder. Which took mediating effect at 29.0% and 20.7% of the total effect. Resilience-self-efficacy had a chain mediated effect between ICU related memory and post-traumatic stress disorder, with an effective value of 0.36, accounting for 15.6% of the total effect. Conclusion The ruminant thinking and ICU related-memory can be inhibited and the post-traumatic stress disorder can be alleviated by improving the mental resilience level of the patients with hepatic ischemia reperfusion injury from ICU.
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Objective To explore the diagnostic value of the quantitative detection of serum miRNA-193a in pulmonary adenocarcinoma.Methods 40 pulmonary adenocarcinoma patients and 40 healthy people were recruited to receive quantitative detection of serum miRNA-193a and CEA.And then the relationship between the concentration of miRNA-193a and CEA was analyze by spearman correlation analysis.12 of the 40 patients underwent operation and the different levels of miRNA-193a expression among pulmonary adenocarcinoma tissues,adjacent tissues and normal tissues was detected by qRT-PCR.The different miRNA-193a levels were compared among groups of by t-test.The diagnostic performance of miRNA-193a was evaluated with receiver operating characteristic curves(ROC) and the area under the curve (AUC) and its 95%CI were calculated.Results The relative expressions of miRNA-193a in pulmonary adenocarcinoma tissues,adjacent tissues and normal tissues were 1.07±0.16;0.80±0.10;0.11±0.07.miRNA-193a expression in pulmonary adenocarcinoma tissues was significantly lower than that in other two groups(P<0.05).The expression of serum miRNA-193a in pulmonary adenocarcinoma group was significantly lower than that in healthy group(P<0.05).There was no correlation between miRNA-193a and CEA(r=0.079,P=0.618).The detection of miRNA-193a yielded a ROC AUC of 0.829(0.741-0.917) in discriminating pulmonary adenocarcinoma from healthy group.Conclusion The relative expression of miRNA-193a in pulmonary adenocarcinoma was significantly lower than that in healthy controls no matter in tissue or serum,serum miRNA-193a may prove to be a non-invasive biomarker for the auxiliary diagnosis of pulmonary adenocarcinoma.
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<p><b>OBJECTIVE</b>To investigate the clinical and biological characteristics of childhood acute myeloid leukemia(AML)with 8;21 translocation.</p><p><b>METHODS</b>A retrospective analysis including clinical information, cell morphology, chromosome, immunophenotype and molecular biology was performed on 41 cases of childhood t(8;21)AML. The control group included 19 cases of AML without t(8;21) translocation detected during the same period.</p><p><b>RESULTS</b>The 41 cases of t(8;21)AML accounted for 68.3% of 60 continuous childhood AML patients. Among them, classical t(8;21) translocation was seen in 29 cases; variant t(8;21) translocation, simple 8q-, near-tetraploidy characterized by the duplication of t(8;21) translocation each came into view in 2 cases; and cryptic t(8;21) translocation was seen in 6 cases. Thirty seven cases (80.4%) belonged to M2 subtype of AML. Most of them had the morphological changes such as the leukemia cells' indent nucleus with a light stain region of perinucleus, basophilic cytoplasm, differentiation with maturation, megaloblastoid changes and nuclear-cytoplasm imbalance; the high expression of CD13 antigen; and the AML1/ETO fusion transcript in 23 cases examined by reverse transcription-polymerase chain reaction (RT-PCR) assay, including 6 cases with normal karyotype. The difference in complete remission rate between t(8;21) positive patients group and t(8;21) negative patients group was not significant in statistics (82.4% vs 75%, P>0.05). However the difference in recurring rate of the leukemia was statistically significant (10.7% vs 41.7%, P<0.05).</p><p><b>CONCLUSION</b>t(8;21)AML is the most frequent type of childhood AML. It is predominantly associated with M2 subtype of AML and has unique morphological, immunological prognostic features .</p>